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In-vivo Cellular and Molecular Imaging Center (ICMIC)





1.         Ackerstaff, E., Glunde, K., and Bhujwalla, Z. M., Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem, 90(3): p. 525-33; 2003
2.         Glunde, K., Guggino, S. E., Ichikawa, Y., and Bhujwalla, Z. M., A novel method of imaging lysosomes in living human mammary epithelial cells. Mol Imaging, 2(1): p. 24-36; 2003
3.         Glunde, K., Guggino, S. E., Solaiyappan, M., Pathak, A. P., Ichikawa, Y., and Bhujwalla, Z. M., Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia, 5(6): p. 533-45; 2003
4.         Artemov, D., Bhujwalla, Z. M., and Bulte, J. W., Magnetic resonance imaging of cell surface receptors using targeted contrast agents. Curr Pharm Biotechnol, 5(6): p. 485-94; 2004
5.         Collis, S. J. and DeWeese, T. L., Enhanced radiation response through directed molecular targeting approaches. Cancer Metastasis Rev, 23(3-4): p. 277-92; 2004
6.         Glunde, K., Jie, C., and Bhujwalla, Z. M., Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res, 64(12): p. 4270-6; 2004
7.         Jacobs, M. A., Ouwerkerk, R., Wolff, A. C., Stearns, V., Bottomley, P. A., Barker, P. B., Argani, P., Khouri, N., Davidson, N. E., Bhujwalla, Z. M., and Bluemke, D. A., Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications. Technol Cancer Res Treat, 3(6): p. 543-50; 2004
8.         Mori, N., Delsite, R., Natarajan, K., Kulawiec, M., Bhujwalla, Z. M., and Singh, K. K., Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline. Mol Imaging, 3(4): p. 319-23; 2004
9.         Pathak, A. P., Gimi, B., Glunde, K., Ackerstaff, E., Artemov, D., and Bhujwalla, Z. M., Molecular and functional imaging of cancer: advances in MRI and MRS. Methods Enzymol, 386: p. 3-60; 2004
10.       Stoeltzing, O., McCarty, M. F., Wey, J. S., Fan, F., Liu, W., Belcheva, A., Bucana, C. D., Semenza, G. L., and Ellis, L. M., Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst, 96(12): p. 946-56; 2004
11.       Winnard, P., Jr., Mironchik, Y., and Raman, V., Robust expression of transgenes in MCF-7 breast cancer cells is expression vector-dependent. Biotechniques, 37(3): p. 370, 372, 374; 2004
12.       Bettegowda, C., Foss, C. A., Cheong, I., Wang, Y., Diaz, L., Agrawal, N., Fox, J., Dick, J., Dang, L. H., Zhou, S., Kinzler, K. W., Vogelstein, B., and Pomper, M. G., Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proc Natl Acad Sci U S A, 102(4): p. 1145-50; 2005
13.       Bonekamp, D., Horska, A., Jacobs, M. A., Arslanoglu, A., and Barker, P. B., Fast method for brain image segmentation: application to proton magnetic resonance spectroscopic imaging. Magn Reson Med, 54(5): p. 1268-72; 2005
14.       Diaz, L. A., Jr., Cheong, I., Foss, C. A., Zhang, X., Peters, B. A., Agrawal, N., Bettegowda, C., Karim, B., Liu, G., Khan, K., Huang, X., Kohli, M., Dang, L. H., Hwang, P., Vogelstein, A., Garrett-Mayer, E., Kobrin, B., Pomper, M., Zhou, S., Kinzler, K. W., Vogelstein, B., and Huso, D. L., Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicol Sci, 88(2): p. 562-75; 2005
15.       Foss, C. A., Mease, R. C., Fan, H., Wang, Y., Ravert, H. T., Dannals, R. F., Olszewski, R. T., Heston, W. D., Kozikowski, A. P., and Pomper, M. G., Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer. Clin Cancer Res, 11(11): p. 4022-8; 2005
16.       Gimi, B., Leong, T., Gu, Z., Yang, M., Artemov, D., Bhujwalla, Z. M., and Gracias, D. H., Self-assembled three dimensional radio frequency (RF) shielded containers for cell encapsulation. Biomed Microdevices, 7(4): p. 341-5; 2005
17.       Gimi, B., Pathak, A. P., Ackerstaff, E., Glunde, K., Artemov, D., and Bhujwalla, Z. M., Molecular Imaging of Cancer: Applications of Magnetic Resonance Methods. Proc IEEE Inst Electr Electron Eng, 93(4): p. 784-799; 2005
18.       Glunde, K., Foss, C. A., Takagi, T., Wildes, F., and Bhujwalla, Z. M., Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors. Bioconjug Chem, 16(4): p. 843-51; 2005
19.       Glunde, K., Raman, V., Mori, N., and Bhujwalla, Z. M., RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res, 65(23): p. 11034-43; 2005
20.       Jacobs, M. A., Barker, P. B., Argani, P., Ouwerkerk, R., Bhujwalla, Z. M., and Bluemke, D. A., Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study. J Magn Reson Imaging, 21(1): p. 23-8; 2005
21.       Mathews, W. B., Foss, C. A., Stoermer, D., Ravert, H. T., Dannals, R. F., Henke, B. R., and Pomper, M. G., Synthesis and biodistribution of (11)C-GW7845, a positron-emitting agonist for peroxisome proliferator-activated receptor-{gamma}. J Nucl Med, 46(10): p. 1719-26; 2005
22.       Restrepo, L., Jacobs, M. A., Barker, P. B., Beauchamp, N. J., Skolasky, R. L., Keswani, S. C., and Wityk, R. J., Etiology of perfusion-diffusion magnetic resonance imaging mismatch patterns. J Neuroimaging, 15(3): p. 254-60; 2005
23.       Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M. A., Melamed, J., and Semenza, G. L., Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res, 65(14): p. 6178-88; 2005
24.       Fayad, L. M., Bluemke, D. A., McCarthy, E. F., Weber, K. L., Barker, P. B., and Jacobs, M. A., Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization. J Magn Reson Imaging, 23(1): p. 23-8; 2006
25.       Gimi, B., Mori, N., Ackerstaff, E., Frost, E. E., Bulte, J. W., and Bhujwalla, Z. M., Noninvasive MRI of endothelial cell response to human breast cancer cells. Neoplasia, 8(3): p. 207-13; 2006
26.       Glunde, K., Ackerstaff, E., Mori, N., Jacobs, M. A., and Bhujwalla, Z. M., Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm, 3(5): p. 496-506; 2006
27.       Glunde, K., Jacobs, M. A., and Bhujwalla, Z. M., Choline metabolism in cancer: implications for diagnosis and therapy. Expert Rev Mol Diagn, 6(6): p. 821-9; 2006
28.       Glunde, K. and Serkova, N. J., Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics, 7(7): p. 1109-23; 2006
29.       Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., and Semenza, G. L., Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res, 66(5): p. 2725-31; 2006
30.       Li, C., Greenwood, T. R., Bhujwalla, Z. M., and Glunde, K., Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging. Org Lett, 8(17): p. 3623-6; 2006
31.       Li, C., Winnard, P. T., Jr., Takagi, T., Artemov, D., and Bhujwalla, Z. M., Multimodal image-guided enzyme/prodrug cancer therapy. J Am Chem Soc, 128(47): p. 15072-3; 2006
32.       Macura, K. J., Ouwerkerk, R., Jacobs, M. A., and Bluemke, D. A., Patterns of enhancement on breast MR images: interpretation and imaging pitfalls. Radiographics, 26(6): p. 1719-34; quiz 1719; 2006
33.       Raman, V., Artemov, D., Pathak, A. P., Winnard, P. T., Jr., McNutt, S., Yudina, A., Bogdanov, A., Jr., and Bhujwalla, Z. M., Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res, 66(20): p. 9929-36; 2006
34.       Winnard, P. T., Jr., Kluth, J. B., and Raman, V., Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer. Neoplasia, 8(10): p. 796-806; 2006
35.       Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., Lee, L. A., Semenza, G. L., and Dang, C. V., HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell, 12(3): p. 230-8; 2007
36.       Gilad, A. A., McMahon, M. T., Walczak, P., Winnard, P. T., Jr., Raman, V., van Laarhoven, H. W., Skoglund, C. M., Bulte, J. W., and van Zijl, P. C., Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol, 25(2): p. 217-9; 2007
37.       Gimi, B., Artemov, D., Leong, T., Gracias, D. H., Gilson, W., Stuber, M., and Bhujwalla, Z. M., Cell viability and noninvasive in vivo MRI tracking of 3D cell encapsulating self-assembled microcontainers. Cell Transplant, 16(4): p. 403-8; 2007
38.       Gimi, B., Artemov, D., Leong, T., Gracias, D. H., and Bhujwalla, Z. M., MRI of regular-shaped cell-encapsulating polyhedral microcontainers. Magn Reson Med, 58(6): p. 1283-7; 2007
39.       Glunde, K., Pathak, A. P., and Bhujwalla, Z. M., Molecular-functional imaging of cancer: to image and imagine. Trends Mol Med, 13(7): p. 287-97; 2007
40.       Jacobs, M. A., Ibrahim, T. S., and Ouwerkerk, R., AAPM/RSNA physics tutorials for residents: MR imaging: brief overview and emerging applications. Radiographics, 27(4): p. 1213-29; 2007
41.       Karagiannis, E. D. and Popel, A. S., Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties. Biochem Biophys Res Commun, 354(2): p. 434-9; 2007
42.       Karagiannis, E. D. and Popel, A. S., Anti-angiogenic peptides identified in thrombospondin type I domains. Biochem Biophys Res Commun, 359(1): p. 63-9; 2007
43.       Karagiannis, E. D. and Popel, A. S., Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells. Int J Biochem Cell Biol, 39(12): p. 2314-23; 2007
44.       Mori, N., Glunde, K., Takagi, T., Raman, V., and Bhujwalla, Z. M., Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells. Cancer Res, 67(23): p. 11284-90; 2007
45.       Ouwerkerk, R., Jacobs, M. A., Macura, K. J., Wolff, A. C., Stearns, V., Mezban, S. D., Khouri, N. F., Bluemke, D. A., and Bottomley, P. A., Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI. Breast Cancer Res Treat, 106(2): p. 151-60; 2007
46.       Qin, J., Laurent, S., Suk, Y., Roch, A., Mikhaylova, M., Bhujwalla, Z. M., Muller, R. N., and Muhammed, M., A high-performance magnetic resonance imaging T2 contrast agent. Adv Mater, 19: p. 1874-1878; 2007
47.       Raman, V., Pathak, A. P., Glunde, K., Artemov, D., and Bhujwalla, Z. M., Magnetic resonance imaging and spectroscopy of transgenic models of cancer. NMR Biomed, 20(3): p. 186-99; 2007
48.       Shan, L., Wang, S., Sridhar, R., Bhujwalla, Z. M., and Wang, P. C., Dual probe with fluorescent and magnetic properties for imaging solid tumor xenografts. Mol Imaging, 6(2): p. 85-95; 2007
49.       Stasinopoulos, I., O'Brien, D. R., Wildes, F., Glunde, K., and Bhujwalla, Z. M., Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. Mol Cancer Res, 5(5): p. 435-42; 2007
50.       Toprak, M. S., Mckenna, B. J., Mikhaylova, M., Herbert Waite, J., and Stucky, G. D., Spontaneous assembly of magnetic microspheres. Adv Mater, 19: p. 1362-1368; 2007
51.       Vogel-Claussen, J., Gimi, B., Artemov, D., and Bhujwalla, Z. M., Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126. Cancer Biol Ther, 6(9): p. 1469-75; 2007
52.       Winnard, P. T., Jr., Kluth, J. B., Kato, Y., Artemov, D., and Raman, V., Development of novel chimeric transmembrane proteins for multimodality imaging of cancer cells. Cancer Biol Ther, 6(12): p. 1889-99; 2007
53.       Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., and Semenza, G. L., HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell, 11(5): p. 407-20; 2007
54.       Zhu, W., Okollie, B., and Artemov, D., Controlled internalization of Her-2/ neu receptors by cross-linking for targeted delivery. Cancer Biol Ther, 6(12): p. 1960-6; 2007
55.       Daldrup-Link, H. E., Hawkins, R. A., Meier, R., Goldsby, R. E., and Artemov, D., Receptor imaging of pediatric tumors: clinical practice and new developments. Pediatr Radiol, 38(11): p. 1154-61; 2008
56.       Glunde, K. and Bhujwalla, Z. M., Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic? J Cell Mol Med, 12(1): p. 187-8; 2008
57.       Glunde, K., Shah, T., Winnard, P. T., Jr., Raman, V., Takagi, T., Vesuna, F., Artemov, D., and Bhujwalla, Z. M., Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. Cancer Res, 68(1): p. 172-80; 2008
58.       Jacobs, M. A., Ouwerkerk, R., Petrowski, K., and Macura, K. J., Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. Top Magn Reson Imaging, 19(6): p. 261-72; 2008
59.       Karagiannis, E. D. and Popel, A. S., Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines. J Cell Biochem, 104(4): p. 1356-63; 2008
60.       Karagiannis, E. D. and Popel, A. S., A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A, 105(37): p. 13775-80; 2008
61.       Li, C., Greenwood, T. R., and Glunde, K., Glucosamine-bound near-infrared fluorescent probes with lysosomal specificity for breast tumor imaging. Neoplasia, 10(4): p. 389-98; 2008
62.       Li, C., Penet, M. F., Winnard, P., Jr., Artemov, D., and Bhujwalla, Z. M., Image-guided enzyme/prodrug cancer therapy. Clin Cancer Res, 14(2): p. 515-22; 2008
63.       Li, C., Wildes, F., Winnard, P., Jr., Artemov, D., Penet, M. F., and Bhujwalla, Z. M., Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy. J Med Chem, 51(12): p. 3572-82; 2008
64.       Macura, K. J., Multiparametric magnetic resonance imaging of the prostate: current status in prostate cancer detection, localization, and staging. Semin Roentgenol, 43(4): p. 303-13; 2008
65.       Mathews, W. B., Murugesan, N., Xia, J., Scheffel, U., Hilton, J., Ravert, H. T., Dannals, R. F., and Szabo, Z., Synthesis and in vivo evaluation of novel PET radioligands for imaging the endothelin-A receptor. J Nucl Med, 49(9): p. 1529-36; 2008
66.       Mease, R. C., Dusich, C. L., Foss, C. A., Ravert, H. T., Dannals, R. F., Seidel, J., Prideaux, A., Fox, J. J., Sgouros, G., Kozikowski, A. P., and Pomper, M. G., N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin Cancer Res, 14(10): p. 3036-43; 2008
67.       Mikhaylova, M., Mori, N., Wildes, F. B., Walczak, P., Gimi, B., and Bhujwalla, Z. M., Hypoxia increases breast cancer cell-induced lymphatic endothelial cell migration. Neoplasia, 10(4): p. 380-9; 2008
68.       Pathak, A. P., Hochfeld, W. E., Goodman, S. L., and Pepper, M. S., Circulating and imaging markers for angiogenesis. Angiogenesis, 11(4): p. 321-35; 2008
69.       Pathak, A. P., Ward, B. D., and Schmainda, K. M., A novel technique for modeling susceptibility-based contrast mechanisms for arbitrary microvascular geometries: the finite perturber method. Neuroimage, 40(3): p. 1130-43; 2008
70.       Penet, M. F., Glunde, K., Jacobs, M. A., Pathak, A. P., and Bhujwalla, Z. M., Molecular and functional MRI of the tumor microenvironment. J Nucl Med, 49(5): p. 687-90; 2008
71.       Shan, L., Hao, Y., Wang, S., Korotcov, A., Zhang, R., Wang, T., Califano, J., Gu, X., Sridhar, R., Bhujwalla, Z. M., and Wang, P. C., Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate. Mol Imaging, 7(1): p. 42-9; 2008
72.       Stasinopoulos, I., Mori, N., and Bhujwalla, Z. M., The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. Neoplasia, 10(11): p. 1163-9; 2008
73.       Winnard, P. T., Jr., Botlagunta, M., Kluth, J. B., Mukadam, S., Krishnamachary, B., Vesuna, F., and Raman, V., Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model. Cancer Gene Ther, 15(10): p. 645-54; 2008
74.       Winnard, P. T., Jr., Pathak, A. P., Dhara, S., Cho, S. Y., Raman, V., and Pomper, M. G., Molecular imaging of metastatic potential. J Nucl Med, 49 Suppl 2: p. 96S-112S; 2008
75.       Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., and Semenza, G. L., Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem, 283(16): p. 10892-903; 2008
76.       Zhu, W., Okollie, B., Bhujwalla, Z. M., and Artemov, D., PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach. Magn Reson Med, 59(4): p. 679-85; 2008
77.       Bhujwalla, Z. M., Molecular and functional imaging of cancer. Conf Proc IEEE Eng Med Biol Soc, 2009: p. 47-9; 2009
78.       El Khouli, R. H., Macura, K. J., Barker, P. B., Elkady, L. M., Jacobs, M. A., Vogel-Claussen, J., and Bluemke, D. A., MRI-guided vacuum-assisted breast biopsy: a phantom and patient evaluation of targeting accuracy. J Magn Reson Imaging, 30(2): p. 424-9; 2009
79.       El Khouli, R. H., Macura, K. J., Barker, P. B., Habba, M. R., Jacobs, M. A., and Bluemke, D. A., Relationship of temporal resolution to diagnostic performance for dynamic contrast enhanced MRI of the breast. J Magn Reson Imaging, 30(5): p. 999-1004; 2009
80.       El Khouli, R. H., Macura, K. J., Jacobs, M. A., Khalil, T. H., Kamel, I. R., Dwyer, A., and Bluemke, D. A., Dynamic contrast-enhanced MRI of the breast: quantitative method for kinetic curve type assessment. AJR Am J Roentgenol, 193(4): p. W295-300; 2009
81.       Glunde, K., Jacobs, M. A., Pathak, A. P., Artemov, D., and Bhujwalla, Z. M., Molecular and functional imaging of breast cancer. NMR Biomed, 22(1): p. 92-103; 2009
82.       Glunde, K. and Stasinopoulos, I., ADAM17: the new face of breast cancer-promoting metalloprotease activity. Cancer Biol Ther, 8(11): p. 1055-7; 2009
83.       Jacobs, M. A., Multiparametric magnetic resonance imaging of breast cancer. J Am Coll Radiol, 6(7): p. 523-6; 2009
84.       Jacobs, M. A., Ouwerkerk, R., Kamel, I., Bottomley, P. A., Bluemke, D. A., and Kim, H. S., Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study. J Magn Reson Imaging, 29(3): p. 649-56; 2009
85.       Jacobs, M. A., Pan, L., and Macura, K. J., Whole-body diffusion-weighted and proton imaging: a review of this emerging technology for monitoring metastatic cancer. Semin Roentgenol, 44(2): p. 111-22; 2009
86.       Kato, Y. and Artemov, D., Monitoring of release of cargo from nanocarriers by MRI/MR spectroscopy (MRS): significance of T2/T2* effect of iron particles. Magn Reson Med, 61(5): p. 1059-65; 2009
87.       Krishnamachary, B., Glunde, K., Wildes, F., Mori, N., Takagi, T., Raman, V., and Bhujwalla, Z. M., Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft. Cancer Res, 69(8): p. 3464-71; 2009
88.       Li, C., Winnard, P., and Bhujwalla, Z. M., Facile synthesis of 1-(acetic acid)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraaza-cyclododeca ne: a reactive precursor chelating agent. Tetrahedron Lett, 50(24): p. 2929-2931; 2009
89.       Mikhaylova, M., Stasinopoulos, I., Kato, Y., Artemov, D., and Bhujwalla, Z. M., Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. Cancer Gene Ther, 16(3): p. 217-26; 2009
90.       Nimmagadda, S., Glunde, K., Pomper, M. G., and Bhujwalla, Z. M., Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells. Neoplasia, 11(5): p. 477-84; 2009
91.       Pathak, A. P., Model system takes us a step closer to efficacious imaging biomarkers of angiogenesis in head and neck cancer. Cancer Biol Ther, 8(23): p. 2284-5; 2009
92.       Pathak, A. P., Magnetic resonance susceptibility based perfusion imaging of tumors using iron oxide nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 1(1): p. 84-97; 2009
93.       Penet, M. F., Pathak, A. P., Raman, V., Ballesteros, P., Artemov, D., and Bhujwalla, Z. M., Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft. Cancer Res, 69(22): p. 8822-9; 2009
94.       Pomper, M. G., Hammond, H., Yu, X., Ye, Z., Foss, C. A., Lin, D. D., Fox, J. J., and Cheng, L., Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models. Cell Res, 19(3): p. 370-9; 2009
95.       Serkova, N. J. and Glunde, K., Metabolomics of cancer. Methods Mol Biol, 520: p. 273-95; 2009
96.       Stasinopoulos, I., O'Brien, D. R., and Bhujwalla, Z. M., Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. Cancer Biol Ther, 8(1): p. 31-5; 2009
97.       Vesuna, F., Lisok, A., Kimble, B., and Raman, V., Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression. Neoplasia, 11(12): p. 1318-28; 2009
98.       Ei Khouli, R. H., Jacobs, M. A., Mezban, S. D., Huang, P., Kamel, I. R., Macura, K. J., and Bluemke, D. A., Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging. Radiology, 256(1): p. 64-73; 2010
99.       Fayad, L. M., Salibi, N., Wang, X., Machado, A. J., Jacobs, M. A., Bluemke, D. A., and Barker, P. B., Quantification of muscle choline concentrations by proton MR spectroscopy at 3 T: technical feasibility. AJR Am J Roentgenol, 194(1): p. W73-9; 2010
100.     Fayad, L. M., Wang, X., Salibi, N., Barker, P. B., Jacobs, M. A., Machado, A. J., Weber, K. L., and Bluemke, D. A., A feasibility study of quantitative molecular characterization of musculoskeletal lesions by proton MR spectroscopy at 3 T. AJR Am J Roentgenol, 195(1): p. W69-75; 2010
101.     Glunde, K., Artemov, D., Penet, M. F., Jacobs, M. A., and Bhujwalla, Z. M., Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev, 110(5): p. 3043-59; 2010
102.     Iorio, E., Ricci, A., Bagnoli, M., Pisanu, M. E., Castellano, G., Di Vito, M., Venturini, E., Glunde, K., Bhujwalla, Z. M., Mezzanzanica, D., Canevari, S., and Podo, F., Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res, 70(5): p. 2126-35; 2010
103.     Jacobs, M. A., D.H., G., and H.S., K., Correlation of T1-weighted and diffusion-weighted imaging after MR-guided high intensity focused ultrasound treatment. Med. Phys., 37: p. 4768-4776; 2010
104.     Jacobs, M. A., Stearns, V., Wolff, A. C., Macura, K., Argani, P., Khouri, N., Tsangaris, T., Barker, P. B., Davidson, N. E., Bhujwalla, Z. M., Bluemke, D. A., and Ouwerkerk, R., Multiparametric Magnetic Resonance Imaging, Spectroscopy and Multinuclear ((23)Na) Imaging Monitoring of Preoperative Chemotherapy for Locally Advanced Breast Cancer. Acad Radiol; 2010
105.     Kakkad, S. M., Solaiyappan, M., O'Rourke, B., Stasinopoulos, I., Ackerstaff, E., Raman, V., Bhujwalla, Z. M., and Glunde, K., Hypoxic tumor microenvironments reduce collagen I fiber density. Neoplasia, 12(8): p. 608-17; 2010
106.     Kato, Y., Holm, D. A., Okollie, B., and Artemov, D., Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy. Neuro Oncol, 12(1): p. 71-9; 2010
107.     Nimmagadda, S., Pullambhatla, M., Stone, K., Green, G., Bhujwalla, Z. M., and Pomper, M. G., Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res, 70(10): p. 3935-44; 2010
108.     Onuki, Y., Jacobs, I., Artemov, D., and Kato, Y., Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique. Biomaterials, 31(27): p. 7132-8; 2010
109.     Pathak, A. P., Penet, M. F., and Bhujwalla, Z. M., MR Molecular Imaging of Tumor Vasculature and Vascular Targets. Adv Genet, 69: p. 1-30; 2010
110.     Penet, M. F., Mikhaylova, M., Li, C., Krishnamachary, B., Glunde, K., Pathak, A. P., and Bhujwalla, Z. M., Applications of molecular MRI and optical imaging in cancer. Future Med Chem, 2(6): p. 975-988; 2010
111.     Shah, T., Wildes, F., Penet, M. F., Winnard, P. T., Jr., Glunde, K., Artemov, D., Ackerstaff, E., Gimi, B., Kakkad, S., Raman, V., and Bhujwalla, Z. M., Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells. NMR Biomed, 23(6): p. 633-42; 2010
112.     Soong, T. R., Pathak, A. P., Asano, H., Fox-Talbot, K., and Baldwin, W. M., 3rd, Lymphatic injury and regeneration in cardiac allografts. Transplantation, 89(5): p. 500-8; 2010
113.     Macura, K., Bonekamp, D., Ei Khouli, R. H., and Jacobs, M. A., Advancements in MR Imaging of the Prostate: From diagnosis to interventions. Radiographics; 2010
114.     Li, C., Penet, M. F., Wildes, F., Takagi, T., Winnard, P. T., Jr., Chen, Z., Artemov, D., and Bhujwalla, Z. M., Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ACS Nano. Nov 23;4(11): p. 6707-16; 2010
115.     Jacobs MA, Gultekin DH, Kim HS., Comparison between diffusion-weighted imaging, T2-weighted, and postcontrast T1-weighted imaging after MR-guided, high intensity, focused ultrasound treatment of uterine leiomyomata: preliminary results. Med Phys. Sep;37(9): p. 4768-76; 2010
116.     Glunde K, Bhujwalla Z. M., Metabolic tumor imaging using magnetic resonance spectroscopy. Semin Oncol. Feb;38(1): p. 26-41; 2011. Review
117.     Zhu W, Artemov D., Biocompatible blood pool MRI contrast agents based on hyaluronan. Contrast Media Mol Imaging. Mar-Apr;6(2): p. 61-8; 2011
118.     Bonekamp D, Jacobs M. A., El-Khouli R, Stoianovici D, Macura K. J., Advancements in MR imaging of the prostate: from diagnosis to interventions. Radiographics. May-Jun;31(3): p. 677-703; 2011. Review
119.     Stasinopoulos I, Penet MF, Chen Z, Kakkad S, Glunde K, Bhujwalla ZM., Exploiting the tumor microenvironment for theranostic imaging. NMR Biomed. Jul;24(6): p. 636-47; 2011. Review
120.     Glunde K, Jiang L, Moestue SA, Gribbestad IS., MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR Biomed. Jul;24(6): p. 673-90; 2011. Review
121.     Wang X, Jacobs MA, Fayad L., Therapeutic response in musculoskeletal soft tissue sarcomas: evaluation by MRI. NMR Biomed. Jul;24(6): p. 750-63; 2011. Review
122.     Penet MF, Gadiya MM, Krishnamachary B, Nimmagadda S, Pomper MG, Artemov D, Bhujwalla ZM., Metabolic signatures imaged in cancer-induced cachexia. Cancer Res. Nov 15;71(22): p. 6948-56; 2011
123.     Shah T, Stasinopoulos I, Wildes F, Kakkad S, Artemov D, Bhujwalla ZM., Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells. NMR Biomed. May;25(5): p. 746-54; 2012
124.     Penet MF, Winnard PT Jr, Jacobs MA, Bhujwalla ZM., Understanding cancer-induced cachexia: imaging the flame and its fuel. Curr Opin Support Palliat Care. Dec;5(4): p. 327-33; 2011. Review
125.     Penet MF, Chen Z, Bhujwalla ZM., MRI of metastasis-permissive microenvironments. Future Oncol. Nov;7(11): p. 1269-84; 2011. Review
126.     Kim E, Zhang J, Hong K, Benoit NE, Pathak AP., Vascular phenotyping of brain tumors using magnetic resonance microscopy (μMRI). J Cereb Blood Flow Metab. Jul;31(7): p. 1623-36; 2011
127.     Harouni AA, Hossain J, Jacobs MA, Osman NF., Improved hardware for higher spatial resolution strain-encoded (SENC) breast MRI for strain measurements. Acad Radiol. Jun;18(6): p. 705-15; 2011
128.     Jacobs MA, Ouwerkerk R, Wolff AC, Gabrielson E, Warzecha H, Jeter S, Bluemke DA, Wahl R, Stearns V., Monitoring of neoadjuvant chemotherapy using multiparametric, ²³Na sodium MR, and multimodality (PET/CT/MRI) imaging in locally advanced breast cancer. Breast Cancer Res Treat. Jul;128(1): p. 119-26; 2011
129.     Pathak AP, Kim E, Zhang J, Jones MV., Three-dimensional imaging of the mouse neurovasculature with magnetic resonance microscopy. PLoS One. 6(7):e22643; 2011
130.     Harouni AA, Jacobs MA, Osman NF., Finding the optimal compression level for strain-encoded (SENC) breast MRI; simulations and phantom experiments. Med Image Comput Comput Assist Interv. 14(Pt 1): p. 444-51; 2011
131.     Glunde K, Bhujwalla ZM, Ronen SM., Choline metabolism in malignant transformation. Nat Rev Cancer. Nov 17;11(12): p. 835-48; 2011. Review
132.     El Khouli RH, Macura KJ, Kamel IR, Jacobs MA, Bluemke DA., 3-T dynamic contrast-enhanced MRI of the breast: pharmacokinetic parameters versus conventional kinetic curve analysis. AJR Am J Roentgenol. Dec;197(6): p. 1498-505; 2011
133.     Subhawong TK, Wang X, Durand DJ, Jacobs MA, Carrino JA, Machado AJ, Fayad LM., Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions. AJR Am J Roentgenol. Jan;198(1): p. 162-72; 2012. Review
134.     Akhbardeh A, Jacobs MA., Comparative analysis of nonlinear dimensionality reduction techniques for breast MRI segmentation. Med Phys. Apr;39(4): p. 2275-89; 2012
135.     Liu G, Chan KW, Song X, Zhang J, Gilad AA, Bulte JW, van Zijl PC, McMahon MT., Normalized magnetization ratio (NOMAR) filtering for creation of tissue selective contrast maps. Magn Reson Med. Apr 12. doi: 10.1002/mrm.24271. [Epub ahead of print]; 2012
136.     Liu W, Glunde K, Bhujwalla ZM, Raman V, Sharma A, Phang JM., Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments. Cancer Res. Jul 15;72(14): p. 3677-86; 2012
138.     Stasinopoulos I, Greenwood T, Glunde K, Bhujwalla ZM., Prostaglandin E(2) promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cells. Prostaglandins Other Lipid Mediat. Oct;99(1-2): p. 9-14; 2012
139.     Chun YS, Yoshida T, Mori T, Huso DL, Zhang Z, Stearns V, Perkins B, Jones RJ, Sukumar S., Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors. Breast Cancer Res Treat. Aug;135(1): p. 201-8; 2012
140.     Yadav NN, Jones CK, Xu J, Bar-Shir A, Gilad AA, McMahon MT, van Zijl PC., Detection of rapidly exchanging compounds using on-resonance frequency-labeled exchange (FLEX) transfer. Magn Reson Med. Oct;68(4): p. 1048-55; 2012
141.     Chen Z, Penet MF, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM., PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy. ACS Nano. Sep 25;6(9):7752-62; 2012
142.     Chan KW, McMahon MT, Kato Y, Liu G, Bulte JW, Bhujwalla ZM, Artemov D, van Zijl PC., Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn Reson Med. 2012 Oct 16. doi: 10.1002/mrm.24520. In press
143.     Kakkad SM, Solaiyappan M, Argani P, Sukumar S, Jacobs LK, Leibfritz D, Bhujwalla ZM, Glunde K, Collagen I fiber density increases in lymph node positive breast cancers in a pilot study. JBO Nov; 2012. In press